Drug interactions
Dolasetron + Formoterol
Severity: Moderate
Dolasetron and Formoterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dolasetron's active metabolite prolongs cardiac conduction intervals including QTc, and formoterol can add to this through beta2 stimulation and lowered potassium. The combination raises the risk of arrhythmia, especially in patients with existing cardiac disease or electrolyte abnormalities.
What this interaction means in plain words
Dolasetron and Formoterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dolasetron belongs to Gastrointestinal Tract; Formoterol belongs to Respiratory.
Why it happens
Additive QT prolongation, compounded by beta2-agonist-induced hypokalemia.
What to do
Check and correct potassium and magnesium, obtain an ECG in high-risk patients, and consider an antiemetic with less QT effect if risk factors are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Formoterol
- Adagrasib + Formoterol Major
- Amiodarone + Formoterol Major
- Amisulpride + Formoterol Major
- Amitriptyline + Formoterol Major
- Amoxapine + Formoterol Major
- Arformoterol + Formoterol Major
Other interactions of Dolasetron
- Apomorphine + Dolasetron Contraindicated
- Dofetilide + Dolasetron Contraindicated
- Dolasetron + Ibutilide Contraindicated
- Dolasetron + Pimozide Contraindicated
- Dolasetron + Thioridazine Contraindicated
- Dolasetron + Vandetanib Contraindicated
Frequently asked questions
Can I take Dolasetron with Formoterol?
MediHelp rates the interaction as moderate. Dolasetron and Formoterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dolasetron's active metabolite prolongs cardiac conduction intervals including QTc, and formoterol can add to this through beta2 stimulation and lowered potassium. The combination raises the risk of arrhythmia, especially in patients with existing cardiac disease or electrolyte abnormalities.
How serious is the interaction between Dolasetron and Formoterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check and correct potassium and magnesium, obtain an ECG in high-risk patients, and consider an antiemetic with less QT effect if risk factors are present.
What other medicines interact with Formoterol?
MediHelp also lists interactions of Formoterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Formoterol page.
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