Drug interactions
Dolasetron + Levosalbutamol
Severity: Moderate
Dolasetron and Levosalbutamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dolasetron prolongs the QT and PR intervals, and levosalbutamol may add arrhythmic risk through hypokalemia and tachycardia. The combination is of most concern in patients with electrolyte disturbances or cardiac disease.
What this interaction means in plain words
Dolasetron and Levosalbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dolasetron belongs to Gastrointestinal Tract; Levosalbutamol belongs to Respiratory.
Why it happens
Additive QT prolongation, with beta-2 agonist-induced hypokalemia contributing.
What to do
Correct potassium and magnesium before use and monitor ECG in high-risk patients. Consider an antiemetic with less QT effect if risk factors are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levosalbutamol
Other interactions of Dolasetron
- Apomorphine + Dolasetron Contraindicated
- Dofetilide + Dolasetron Contraindicated
- Dolasetron + Ibutilide Contraindicated
- Dolasetron + Pimozide Contraindicated
- Dolasetron + Thioridazine Contraindicated
- Dolasetron + Vandetanib Contraindicated
Frequently asked questions
Can I take Dolasetron with Levosalbutamol?
MediHelp rates the interaction as moderate. Dolasetron and Levosalbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dolasetron prolongs the QT and PR intervals, and levosalbutamol may add arrhythmic risk through hypokalemia and tachycardia. The combination is of most concern in patients with electrolyte disturbances or cardiac disease.
How serious is the interaction between Dolasetron and Levosalbutamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Correct potassium and magnesium before use and monitor ECG in high-risk patients. Consider an antiemetic with less QT effect if risk factors are present.
What other medicines interact with Levosalbutamol?
MediHelp also lists interactions of Levosalbutamol with, for example, Amisulpride, Carvedilol, Fexinidazole. The full list is on the Levosalbutamol page.
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