Drug interactions
Dolasetron + Lofepramine
Severity: Moderate
Dolasetron and Lofepramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lofepramine is a tricyclic antidepressant that can prolong the QT interval and slow conduction. With dolasetron the combined effects on cardiac conduction and repolarization raise arrhythmia risk.
What this interaction means in plain words
Dolasetron and Lofepramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive effects on cardiac conduction and QT prolongation.
What to do
Obtain a baseline ECG and correct potassium and magnesium. Monitor ECG during coadministration, particularly in patients with cardiac disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dolasetron
- Apomorphine + Dolasetron Contraindicated
- Dofetilide + Dolasetron Contraindicated
- Dolasetron + Ibutilide Contraindicated
- Dolasetron + Pimozide Contraindicated
- Dolasetron + Thioridazine Contraindicated
- Dolasetron + Vandetanib Contraindicated
Frequently asked questions
Can I take Dolasetron with Lofepramine?
MediHelp rates the interaction as moderate. Dolasetron and Lofepramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lofepramine is a tricyclic antidepressant that can prolong the QT interval and slow conduction. With dolasetron the combined effects on cardiac conduction and repolarization raise arrhythmia risk.
How serious is the interaction between Dolasetron and Lofepramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium. Monitor ECG during coadministration, particularly in patients with cardiac disease.
What other medicines interact with Dolasetron?
MediHelp also lists interactions of Dolasetron with, for example, Apomorphine, Dofetilide, Ibutilide. The full list is on the Dolasetron page.
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