Drug interactions
Dolasetron + Octreotide
Severity: Moderate
Dolasetron and Octreotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Octreotide can cause bradycardia and conduction abnormalities, and QT prolongation has been reported. With dolasetron the cardiac effects may add up, though clinical reports are limited.
What this interaction means in plain words
Dolasetron and Octreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dolasetron belongs to Gastrointestinal Tract; Octreotide belongs to Endocrine.
Why it happens
Additive effects on cardiac conduction and repolarization; octreotide-induced bradycardia may further favor arrhythmia.
What to do
Monitor ECG and heart rate when starting the combination, especially in patients with heart disease or electrolyte disturbance. Correct potassium and magnesium abnormalities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dolasetron
- Apomorphine + Dolasetron Contraindicated
- Dofetilide + Dolasetron Contraindicated
- Dolasetron + Ibutilide Contraindicated
- Dolasetron + Pimozide Contraindicated
- Dolasetron + Thioridazine Contraindicated
- Dolasetron + Vandetanib Contraindicated
Other interactions of Octreotide
Frequently asked questions
Can I take Dolasetron with Octreotide?
MediHelp rates the interaction as moderate. Dolasetron and Octreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Octreotide can cause bradycardia and conduction abnormalities, and QT prolongation has been reported. With dolasetron the cardiac effects may add up, though clinical reports are limited.
How serious is the interaction between Dolasetron and Octreotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and heart rate when starting the combination, especially in patients with heart disease or electrolyte disturbance. Correct potassium and magnesium abnormalities.
What other medicines interact with Dolasetron?
MediHelp also lists interactions of Dolasetron with, for example, Apomorphine, Dofetilide, Ibutilide. The full list is on the Dolasetron page.
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