Drug interactions
Dolasetron + Olanzapine
Severity: Moderate
Dolasetron and Olanzapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine has a small effect on QT, and dolasetron prolongs cardiac intervals, so the combination may add to arrhythmia risk. The concern is greatest in patients with other QT risk factors.
What this interaction means in plain words
Dolasetron and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dolasetron belongs to Gastrointestinal Tract; Olanzapine belongs to Central Nervous System.
Why it happens
Additive effects on ventricular repolarization.
What to do
Monitor ECG in patients with cardiac risk factors and correct electrolyte abnormalities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dolasetron
- Apomorphine + Dolasetron Contraindicated
- Dofetilide + Dolasetron Contraindicated
- Dolasetron + Ibutilide Contraindicated
- Dolasetron + Pimozide Contraindicated
- Dolasetron + Thioridazine Contraindicated
- Dolasetron + Vandetanib Contraindicated
Other interactions of Olanzapine
Frequently asked questions
Can I take Dolasetron with Olanzapine?
MediHelp rates the interaction as moderate. Dolasetron and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine has a small effect on QT, and dolasetron prolongs cardiac intervals, so the combination may add to arrhythmia risk. The concern is greatest in patients with other QT risk factors.
How serious is the interaction between Dolasetron and Olanzapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG in patients with cardiac risk factors and correct electrolyte abnormalities.
What other medicines interact with Dolasetron?
MediHelp also lists interactions of Dolasetron with, for example, Apomorphine, Dofetilide, Ibutilide. The full list is on the Dolasetron page.
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