Drug interactions
Dolasetron + Promazine
Severity: Moderate
Dolasetron and Promazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Promazine is a phenothiazine antipsychotic that can prolong the QT interval. With dolasetron, additive QT prolongation raises the risk of torsades de pointes.
What this interaction means in plain words
Dolasetron and Promazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Use an antiemetic with less QT effect if possible. Otherwise obtain a baseline ECG, correct electrolytes and monitor ECG.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dolasetron
- Apomorphine + Dolasetron Contraindicated
- Dofetilide + Dolasetron Contraindicated
- Dolasetron + Ibutilide Contraindicated
- Dolasetron + Pimozide Contraindicated
- Dolasetron + Thioridazine Contraindicated
- Dolasetron + Vandetanib Contraindicated
Frequently asked questions
Can I take Dolasetron with Promazine?
MediHelp rates the interaction as moderate. Dolasetron and Promazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Promazine is a phenothiazine antipsychotic that can prolong the QT interval. With dolasetron, additive QT prolongation raises the risk of torsades de pointes.
How serious is the interaction between Dolasetron and Promazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an antiemetic with less QT effect if possible. Otherwise obtain a baseline ECG, correct electrolytes and monitor ECG.
What other medicines interact with Dolasetron?
MediHelp also lists interactions of Dolasetron with, for example, Apomorphine, Dofetilide, Ibutilide. The full list is on the Dolasetron page.
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