Drug interactions
Dolasetron + Romidepsin
Severity: Major
Dolasetron and Romidepsin: major interaction.
Last updated Sources: Health Canada product monograph
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Romidepsin has been associated with ECG changes including QT prolongation, and dolasetron also prolongs QTc. Used together they may increase the risk of serious ventricular arrhythmias, particularly given the frequent nausea and electrolyte shifts with romidepsin.
What this interaction means in plain words
Dolasetron and Romidepsin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Choose a different antiemetic when possible. If dolasetron is needed, correct potassium and magnesium and monitor the ECG.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Dolasetron
- Apomorphine + Dolasetron Contraindicated
- Dofetilide + Dolasetron Contraindicated
- Dolasetron + Ibutilide Contraindicated
- Dolasetron + Pimozide Contraindicated
- Dolasetron + Thioridazine Contraindicated
- Dolasetron + Vandetanib Contraindicated
Frequently asked questions
Can I take Dolasetron with Romidepsin?
MediHelp rates the interaction as major. Dolasetron and Romidepsin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Romidepsin has been associated with ECG changes including QT prolongation, and dolasetron also prolongs QTc. Used together they may increase the risk of serious ventricular arrhythmias, particularly given the frequent nausea and electrolyte shifts with romidepsin.
How serious is the interaction between Dolasetron and Romidepsin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Choose a different antiemetic when possible. If dolasetron is needed, correct potassium and magnesium and monitor the ECG.
What other medicines interact with Dolasetron?
MediHelp also lists interactions of Dolasetron with, for example, Apomorphine, Dofetilide, Ibutilide. The full list is on the Dolasetron page.
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