Drug interactions
Dolasetron + Umeclidinium bromide / vilanterol inhaled
Severity: Moderate
Dolasetron and Umeclidinium bromide / vilanterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vilanterol is a beta-agonist that can prolong QTc and cause tachycardia and hypokalemia, and dolasetron also prolongs QTc. Systemic exposure from inhalation is low, so the risk is smaller than with oral QT drugs but may matter in susceptible patients.
What this interaction means in plain words
Dolasetron and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation, with beta-agonist-induced hypokalemia and tachycardia adding to arrhythmic risk.
What to do
Monitor ECG and potassium in patients with cardiac disease or other QT risk factors. Prefer a different antiemetic when feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dolasetron
- Apomorphine + Dolasetron Contraindicated
- Dofetilide + Dolasetron Contraindicated
- Dolasetron + Ibutilide Contraindicated
- Dolasetron + Pimozide Contraindicated
- Dolasetron + Thioridazine Contraindicated
- Dolasetron + Vandetanib Contraindicated
Frequently asked questions
Can I take Dolasetron with Umeclidinium bromide / vilanterol inhaled?
MediHelp rates the interaction as moderate. Dolasetron and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vilanterol is a beta-agonist that can prolong QTc and cause tachycardia and hypokalemia, and dolasetron also prolongs QTc. Systemic exposure from inhalation is low, so the risk is smaller than with oral QT drugs but may matter in susceptible patients.
How serious is the interaction between Dolasetron and Umeclidinium bromide / vilanterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and potassium in patients with cardiac disease or other QT risk factors. Prefer a different antiemetic when feasible.
What other medicines interact with Dolasetron?
MediHelp also lists interactions of Dolasetron with, for example, Apomorphine, Dofetilide, Ibutilide. The full list is on the Dolasetron page.
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