Drug interactions
Dolasetron + Venlafaxine
Severity: Moderate
Dolasetron and Venlafaxine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Venlafaxine is a serotonergic antidepressant that can add to serotonin syndrome risk with 5-HT3 antagonists, and it has some QT effect at high doses. The combination is usually tolerated, but serious reactions are possible.
What this interaction means in plain words
Dolasetron and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dolasetron belongs to Gastrointestinal Tract; Venlafaxine belongs to Central Nervous System.
Why it happens
Possible additive serotonergic effect and minor additive QT prolongation.
What to do
Monitor for serotonin toxicity and consider an ECG in patients with cardiac risk factors. Stop the agents if symptoms emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dolasetron
- Apomorphine + Dolasetron Contraindicated
- Dofetilide + Dolasetron Contraindicated
- Dolasetron + Ibutilide Contraindicated
- Dolasetron + Pimozide Contraindicated
- Dolasetron + Thioridazine Contraindicated
- Dolasetron + Vandetanib Contraindicated
Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Frequently asked questions
Can I take Dolasetron with Venlafaxine?
MediHelp rates the interaction as moderate. Dolasetron and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Venlafaxine is a serotonergic antidepressant that can add to serotonin syndrome risk with 5-HT3 antagonists, and it has some QT effect at high doses. The combination is usually tolerated, but serious reactions are possible.
How serious is the interaction between Dolasetron and Venlafaxine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for serotonin toxicity and consider an ECG in patients with cardiac risk factors. Stop the agents if symptoms emerge.
What other medicines interact with Dolasetron?
MediHelp also lists interactions of Dolasetron with, for example, Apomorphine, Dofetilide, Ibutilide. The full list is on the Dolasetron page.
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