Drug interactions
Dolutegravir + Fosamprenavir
Severity: Moderate
Dolutegravir and Fosamprenavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir-boosted fosamprenavir lowers dolutegravir exposure. Without adjustment, this may lead to suboptimal antiviral activity, particularly in integrase-experienced patients.
What this interaction means in plain words
Dolutegravir and Fosamprenavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Boosted fosamprenavir induces UGT1A1 and CYP3A4, increasing dolutegravir clearance.
What to do
Give dolutegravir 50 mg twice daily with fosamprenavir/ritonavir in integrase-naive patients, and avoid the combination if integrase resistance is present. Monitor viral load.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dolutegravir
Frequently asked questions
Can I take Dolutegravir with Fosamprenavir?
MediHelp rates the interaction as moderate. Dolutegravir and Fosamprenavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ritonavir-boosted fosamprenavir lowers dolutegravir exposure. Without adjustment, this may lead to suboptimal antiviral activity, particularly in integrase-experienced patients.
How serious is the interaction between Dolutegravir and Fosamprenavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give dolutegravir 50 mg twice daily with fosamprenavir/ritonavir in integrase-naive patients, and avoid the combination if integrase resistance is present. Monitor viral load.
What other medicines interact with Dolutegravir?
MediHelp also lists interactions of Dolutegravir with, for example, Dofetilide, Aluminum hydroxide, Atidarsagene autotemcel. The full list is on the Dolutegravir page.
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