Drug interactions
Dolutegravir + Magnesium gluconate
Severity: Moderate
Dolutegravir and Magnesium gluconate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Magnesium binds dolutegravir in the gut and lowers its absorption. This can result in subtherapeutic levels and risk virologic failure.
What this interaction means in plain words
Dolutegravir and Magnesium gluconate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Magnesium cations chelate dolutegravir in the gastrointestinal tract, reducing absorption.
What to do
Give dolutegravir at least 2 hours before or 6 hours after magnesium supplements, or take both together with food.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dolutegravir
Frequently asked questions
Can I take Dolutegravir with Magnesium gluconate?
MediHelp rates the interaction as moderate. Dolutegravir and Magnesium gluconate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Magnesium binds dolutegravir in the gut and lowers its absorption. This can result in subtherapeutic levels and risk virologic failure.
How serious is the interaction between Dolutegravir and Magnesium gluconate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give dolutegravir at least 2 hours before or 6 hours after magnesium supplements, or take both together with food.
What other medicines interact with Dolutegravir?
MediHelp also lists interactions of Dolutegravir with, for example, Dofetilide, Aluminum hydroxide, Atidarsagene autotemcel. The full list is on the Dolutegravir page.
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