Drug interactions
Dolutegravir + Magnesium supplement
Severity: Moderate
Dolutegravir and Magnesium supplement: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral magnesium supplements can markedly reduce dolutegravir absorption, potentially causing subtherapeutic levels and virologic failure. The effect is greatest under fasting conditions.
What this interaction means in plain words
Dolutegravir and Magnesium supplement can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Magnesium cations form chelate complexes with dolutegravir in the gut, decreasing absorption.
What to do
Take dolutegravir 2 hours before or 6 hours after magnesium supplements.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dolutegravir
Frequently asked questions
Can I take Dolutegravir with Magnesium supplement?
MediHelp rates the interaction as moderate. Dolutegravir and Magnesium supplement can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral magnesium supplements can markedly reduce dolutegravir absorption, potentially causing subtherapeutic levels and virologic failure. The effect is greatest under fasting conditions.
How serious is the interaction between Dolutegravir and Magnesium supplement?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take dolutegravir 2 hours before or 6 hours after magnesium supplements.
What other medicines interact with Dolutegravir?
MediHelp also lists interactions of Dolutegravir with, for example, Dofetilide, Aluminum hydroxide, Atidarsagene autotemcel. The full list is on the Dolutegravir page.
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