Drug interactions
Dolutegravir + Multivitamins
Severity: Moderate
Dolutegravir and Multivitamins: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Multivitamins containing iron, calcium, magnesium or zinc can reduce dolutegravir absorption and lower plasma levels. This could compromise viral suppression if doses are not separated.
What this interaction means in plain words
Dolutegravir and Multivitamins can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Polyvalent cations in the multivitamin chelate dolutegravir in the gastrointestinal tract.
What to do
Take dolutegravir 2 hours before or 6 hours after the multivitamin, or take both together with a meal.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dolutegravir
Frequently asked questions
Can I take Dolutegravir with Multivitamins?
MediHelp rates the interaction as moderate. Dolutegravir and Multivitamins can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Multivitamins containing iron, calcium, magnesium or zinc can reduce dolutegravir absorption and lower plasma levels. This could compromise viral suppression if doses are not separated.
How serious is the interaction between Dolutegravir and Multivitamins?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take dolutegravir 2 hours before or 6 hours after the multivitamin, or take both together with a meal.
What other medicines interact with Dolutegravir?
MediHelp also lists interactions of Dolutegravir with, for example, Dofetilide, Aluminum hydroxide, Atidarsagene autotemcel. The full list is on the Dolutegravir page.
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