Drug interactions
Dolutegravir + Prussian blue
Severity: Moderate
Dolutegravir and Prussian blue: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Prussian blue is an insoluble ferric hexacyanoferrate that may bind dolutegravir in the gut. This could reduce dolutegravir absorption, though it is mostly used short term.
What this interaction means in plain words
Dolutegravir and Prussian blue can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible binding of dolutegravir in the gastrointestinal lumen reduces its absorption; this is predicted rather than well established.
What to do
Separate dolutegravir from Prussian blue by at least 2 hours before or 6 hours after. Monitor virologic response if prolonged Prussian blue therapy is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dolutegravir
Frequently asked questions
Can I take Dolutegravir with Prussian blue?
MediHelp rates the interaction as moderate. Dolutegravir and Prussian blue can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Prussian blue is an insoluble ferric hexacyanoferrate that may bind dolutegravir in the gut. This could reduce dolutegravir absorption, though it is mostly used short term.
How serious is the interaction between Dolutegravir and Prussian blue?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate dolutegravir from Prussian blue by at least 2 hours before or 6 hours after. Monitor virologic response if prolonged Prussian blue therapy is needed.
What other medicines interact with Dolutegravir?
MediHelp also lists interactions of Dolutegravir with, for example, Dofetilide, Aluminum hydroxide, Atidarsagene autotemcel. The full list is on the Dolutegravir page.
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