Drug interactions
dolutegravir + rifampin
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
↓ dolutegravir; virologic failure risk.
Mechanism of action
UGT1A1/CYP3A induction.
Clinical management
Avoid or increase DTG dose per guidelines.
Drug reference
References
Frequently asked questions
Can I take dolutegravir with rifampin?
The interaction is rated: Major. ↓ dolutegravir; virologic failure risk.
How serious is the interaction between dolutegravir and rifampin?
The interaction is rated: Major. Evidence level: High.
How is the interaction between dolutegravir and rifampin managed?
Avoid or increase DTG dose per guidelines.
Why do dolutegravir and rifampin interact?
UGT1A1/CYP3A induction.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.