Drug interactions
Dolutegravir + Selenium
Severity: Minor
Dolutegravir and Selenium: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral mineral supplements containing selenium may bind dolutegravir in the gut and lower its absorption. This could reduce antiviral efficacy if doses are taken together.
What this interaction means in plain words
Dolutegravir and Selenium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dolutegravir belongs to Anti Virals; Selenium belongs to Gastrointestinal Tract.
Why it happens
Possible chelation of dolutegravir by supplement cations in the gastrointestinal tract, extrapolated from other polyvalent cations.
What to do
Take dolutegravir at least 2 hours before or 6 hours after selenium-containing supplements. Alternatively, take both together with food.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dolutegravir
Other interactions of Selenium
- Alendronate + Selenium Moderate
- Eltrombopag + Selenium Moderate
- Ibandronate + Selenium Moderate
- Penicillamine + Selenium Moderate
- Risedronate + Selenium Moderate
- Baloxavir marboxil + Selenium Minor
Frequently asked questions
Can I take Dolutegravir with Selenium?
MediHelp rates the interaction as minor. Dolutegravir and Selenium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oral mineral supplements containing selenium may bind dolutegravir in the gut and lower its absorption. This could reduce antiviral efficacy if doses are taken together.
How serious is the interaction between Dolutegravir and Selenium?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take dolutegravir at least 2 hours before or 6 hours after selenium-containing supplements. Alternatively, take both together with food.
What other medicines interact with Dolutegravir?
MediHelp also lists interactions of Dolutegravir with, for example, Dofetilide, Aluminum hydroxide, Atidarsagene autotemcel. The full list is on the Dolutegravir page.
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