Drug interactions
Dolutegravir + Sodium sulfate / ?magnesium sulfate / potassium chloride
Severity: Moderate
Dolutegravir and Sodium sulfate / ?magnesium sulfate / potassium chloride: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral sulfate-based bowel preparations contain magnesium that can chelate dolutegravir and reduce its absorption. A missed or reduced dose around colonoscopy preparation could lower drug exposure; rapid transit may add to the effect.
What this interaction means in plain words
Dolutegravir and Sodium sulfate / ?magnesium sulfate / potassium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Magnesium cations chelate dolutegravir in the gut, reducing absorption.
What to do
Take dolutegravir at least 2 hours before or 6 hours after each dose of the bowel preparation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dolutegravir
Frequently asked questions
Can I take Dolutegravir with Sodium sulfate / ?magnesium sulfate / potassium chloride?
MediHelp rates the interaction as moderate. Dolutegravir and Sodium sulfate / ?magnesium sulfate / potassium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral sulfate-based bowel preparations contain magnesium that can chelate dolutegravir and reduce its absorption. A missed or reduced dose around colonoscopy preparation could lower drug exposure; rapid transit may add to the effect.
How serious is the interaction between Dolutegravir and Sodium sulfate / ?magnesium sulfate / potassium chloride?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take dolutegravir at least 2 hours before or 6 hours after each dose of the bowel preparation.
What other medicines interact with Dolutegravir?
MediHelp also lists interactions of Dolutegravir with, for example, Dofetilide, Aluminum hydroxide, Atidarsagene autotemcel. The full list is on the Dolutegravir page.
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