Drug interactions
Donepezil + Fluconazole
Severity: Moderate
Donepezil and Fluconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, and donepezil has been linked to torsades de pointes and bradycardia. Fluconazole may also modestly raise donepezil levels through CYP3A4 inhibition.
What this interaction means in plain words
Donepezil and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Donepezil belongs to Central Nervous System; Fluconazole belongs to Anti Fungals.
Why it happens
Additive QT prolongation, with possible CYP3A4 inhibition raising donepezil exposure.
What to do
Check ECG and correct potassium and magnesium before combining, especially in older patients or those with bradycardia. Monitor for syncope, palpitations and cholinergic effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Donepezil
- Donepezil + Dronedarone Contraindicated
- Donepezil + Pimozide Contraindicated
- Donepezil + Thioridazine Contraindicated
- Donepezil + Vandetanib Contraindicated
- Amiodarone + Donepezil Major
- Amisulpride + Donepezil Major
Frequently asked questions
Can I take Donepezil with Fluconazole?
MediHelp rates the interaction as moderate. Donepezil and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, and donepezil has been linked to torsades de pointes and bradycardia. Fluconazole may also modestly raise donepezil levels through CYP3A4 inhibition.
How serious is the interaction between Donepezil and Fluconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and correct potassium and magnesium before combining, especially in older patients or those with bradycardia. Monitor for syncope, palpitations and cholinergic effects.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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