Drug interactions
Donepezil + Goserelin
Severity: Moderate
Donepezil and Goserelin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen deprivation with goserelin can prolong the QT interval, and donepezil has also been linked to QT prolongation. Together they may increase arrhythmia risk, especially with other risk factors.
What this interaction means in plain words
Donepezil and Goserelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Donepezil belongs to Central Nervous System; Goserelin belongs to Endocrine.
Why it happens
Additive QT prolongation.
What to do
Check a baseline ECG and electrolytes and repeat periodically in patients with cardiac risk factors. Avoid other QT-prolonging drugs where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Donepezil
- Donepezil + Dronedarone Contraindicated
- Donepezil + Pimozide Contraindicated
- Donepezil + Thioridazine Contraindicated
- Donepezil + Vandetanib Contraindicated
- Amiodarone + Donepezil Major
- Amisulpride + Donepezil Major
Other interactions of Goserelin
Frequently asked questions
Can I take Donepezil with Goserelin?
MediHelp rates the interaction as moderate. Donepezil and Goserelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgen deprivation with goserelin can prolong the QT interval, and donepezil has also been linked to QT prolongation. Together they may increase arrhythmia risk, especially with other risk factors.
How serious is the interaction between Donepezil and Goserelin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and electrolytes and repeat periodically in patients with cardiac risk factors. Avoid other QT-prolonging drugs where possible.
What other medicines interact with Donepezil?
MediHelp also lists interactions of Donepezil with, for example, Dronedarone, Pimozide, Thioridazine. The full list is on the Donepezil page.
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