Drug interactions
Donepezil + Indacaterol
Severity: Moderate
Donepezil and Indacaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Donepezil can cause bradycardia and QT prolongation, and indacaterol may add cardiac effects such as tachycardia and hypokalemia. The combination may modestly increase arrhythmia risk, particularly in older patients or those with other risk factors.
What this interaction means in plain words
Donepezil and Indacaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Donepezil belongs to Central Nervous System; Indacaterol belongs to Respiratory.
Why it happens
Additive pharmacodynamic QT prolongation, with beta-2 agonist related hypokalemia.
What to do
Monitor heart rate and ECG in patients with cardiac disease or other QT-prolonging drugs. Keep potassium and magnesium within normal range.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol
Other interactions of Donepezil
- Donepezil + Dronedarone Contraindicated
- Donepezil + Pimozide Contraindicated
- Donepezil + Thioridazine Contraindicated
- Donepezil + Vandetanib Contraindicated
- Amiodarone + Donepezil Major
- Amisulpride + Donepezil Major
Frequently asked questions
Can I take Donepezil with Indacaterol?
MediHelp rates the interaction as moderate. Donepezil and Indacaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Donepezil can cause bradycardia and QT prolongation, and indacaterol may add cardiac effects such as tachycardia and hypokalemia. The combination may modestly increase arrhythmia risk, particularly in older patients or those with other risk factors.
How serious is the interaction between Donepezil and Indacaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and ECG in patients with cardiac disease or other QT-prolonging drugs. Keep potassium and magnesium within normal range.
What other medicines interact with Indacaterol?
MediHelp also lists interactions of Indacaterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Indacaterol page.
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