Drug interactions
Donepezil + Ozanimod
Severity: Moderate
Donepezil and Ozanimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ozanimod can slow heart rate and conduction, and donepezil can cause bradycardia and QT prolongation. Together they may increase the risk of bradyarrhythmia and, less commonly, torsades de pointes.
What this interaction means in plain words
Donepezil and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Donepezil belongs to Central Nervous System; Ozanimod belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic effects on heart rate, conduction and repolarisation.
What to do
Obtain a baseline ECG before starting ozanimod and monitor heart rate during titration. Watch for syncope or dizziness and reconsider therapy if bradycardia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Donepezil
- Donepezil + Dronedarone Contraindicated
- Donepezil + Pimozide Contraindicated
- Donepezil + Thioridazine Contraindicated
- Donepezil + Vandetanib Contraindicated
- Amiodarone + Donepezil Major
- Amisulpride + Donepezil Major
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Donepezil with Ozanimod?
MediHelp rates the interaction as moderate. Donepezil and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ozanimod can slow heart rate and conduction, and donepezil can cause bradycardia and QT prolongation. Together they may increase the risk of bradyarrhythmia and, less commonly, torsades de pointes.
How serious is the interaction between Donepezil and Ozanimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG before starting ozanimod and monitor heart rate during titration. Watch for syncope or dizziness and reconsider therapy if bradycardia develops.
What other medicines interact with Donepezil?
MediHelp also lists interactions of Donepezil with, for example, Dronedarone, Pimozide, Thioridazine. The full list is on the Donepezil page.
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