Drug interactions
Isocarboxazid + Ozanimod
Severity: Contraindicated
Isocarboxazid and Ozanimod: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ozanimod's active metabolites are formed and may inhibit MAO-B, and combining with a nonselective MAOI may raise the risk of hypertensive crisis or serotonin toxicity. Clinical interaction data are limited, but labeling advises against the combination.
What this interaction means in plain words
Isocarboxazid and Ozanimod are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Isocarboxazid belongs to Central Nervous System; Ozanimod belongs to Central Nervous System.
Why it happens
Additive MAO inhibition, with ozanimod metabolites contributing to MAO-B inhibition.
What to do
Do not co-administer; allow at least 14 days between stopping either agent and starting the other.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Isocarboxazid
- 5-HTP + Isocarboxazid Contraindicated
- Amitriptyline + Isocarboxazid Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amoxapine + Isocarboxazid Contraindicated
- Apraclonidine + Isocarboxazid Contraindicated
- Atomoxetine + Isocarboxazid Contraindicated
Other interactions of Ozanimod
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
- Ozanimod + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Isocarboxazid with Ozanimod?
MediHelp rates the interaction as contraindicated. Isocarboxazid and Ozanimod are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ozanimod's active metabolites are formed and may inhibit MAO-B, and combining with a nonselective MAOI may raise the risk of hypertensive crisis or serotonin toxicity. Clinical interaction data are limited, but labeling advises against the combination.
How serious is the interaction between Isocarboxazid and Ozanimod?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; allow at least 14 days between stopping either agent and starting the other.
What other medicines interact with Isocarboxazid?
MediHelp also lists interactions of Isocarboxazid with, for example, 5-HTP, Amitriptyline, Amobarbital. The full list is on the Isocarboxazid page.
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