Drug interactions
Donepezil + Tiotropium-olodaterol
Severity: Moderate
Donepezil and Tiotropium-olodaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Donepezil enhances cholinergic transmission whereas tiotropium blocks muscarinic receptors, so the two may partly oppose each other. Donepezil can also cause bradycardia and QT prolongation, and olodaterol may add to QT effects and heart rate changes.
What this interaction means in plain words
Donepezil and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Donepezil belongs to Central Nervous System; Tiotropium-olodaterol belongs to Respiratory.
Why it happens
Pharmacodynamic opposition at muscarinic receptors plus possible additive QT prolongation from donepezil and the beta2 agonist.
What to do
Monitor respiratory symptoms and heart rate, and check an ECG in patients with other QT risk factors. Review the need for the combination if cognitive or bronchodilator response is reduced.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Donepezil and Tiotropium-olodaterol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Tiotropium-olodaterol
Other interactions of Donepezil
- Donepezil + Dronedarone Contraindicated
- Donepezil + Pimozide Contraindicated
- Donepezil + Thioridazine Contraindicated
- Donepezil + Vandetanib Contraindicated
- Amiodarone + Donepezil Major
- Amisulpride + Donepezil Major
Frequently asked questions
Can I take Donepezil with Tiotropium-olodaterol?
MediHelp rates the interaction as moderate. Donepezil and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Donepezil enhances cholinergic transmission whereas tiotropium blocks muscarinic receptors, so the two may partly oppose each other. Donepezil can also cause bradycardia and QT prolongation, and olodaterol may add to QT effects and heart rate changes.
How serious is the interaction between Donepezil and Tiotropium-olodaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor respiratory symptoms and heart rate, and check an ECG in patients with other QT risk factors. Review the need for the combination if cognitive or bronchodilator response is reduced.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
