Drug interactions
Donepezil + Triclabendazole
Severity: Moderate
Donepezil and Triclabendazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triclabendazole can prolong the QT interval, and donepezil may add to this effect. The risk is greater with electrolyte disturbances or other QT-prolonging drugs.
What this interaction means in plain words
Donepezil and Triclabendazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Donepezil belongs to Central Nervous System; Triclabendazole belongs to Anti Parasitic.
Why it happens
Additive QT prolongation.
What to do
Check an ECG and correct electrolyte abnormalities before treatment in patients with risk factors. Avoid other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Donepezil
- Donepezil + Dronedarone Contraindicated
- Donepezil + Pimozide Contraindicated
- Donepezil + Thioridazine Contraindicated
- Donepezil + Vandetanib Contraindicated
- Amiodarone + Donepezil Major
- Amisulpride + Donepezil Major
Other interactions of Triclabendazole
Frequently asked questions
Can I take Donepezil with Triclabendazole?
MediHelp rates the interaction as moderate. Donepezil and Triclabendazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Triclabendazole can prolong the QT interval, and donepezil may add to this effect. The risk is greater with electrolyte disturbances or other QT-prolonging drugs.
How serious is the interaction between Donepezil and Triclabendazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check an ECG and correct electrolyte abnormalities before treatment in patients with risk factors. Avoid other QT-prolonging drugs.
What other medicines interact with Donepezil?
MediHelp also lists interactions of Donepezil with, for example, Dronedarone, Pimozide, Thioridazine. The full list is on the Donepezil page.
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