Drug interactions
Dopamine + Epinephrine
Severity: Moderate
Dopamine and Epinephrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents are sympathomimetics and their effects add together, causing greater increases in heart rate and blood pressure. Combined use raises the risk of tachyarrhythmias and myocardial ischemia, although it is sometimes done deliberately in shock.
What this interaction means in plain words
Dopamine and Epinephrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dopamine belongs to Cardiovascular; Epinephrine belongs to Endocrine.
Why it happens
Additive stimulation of alpha and beta adrenergic receptors.
What to do
Use continuous ECG and arterial blood pressure monitoring and titrate each infusion to the lowest effective dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dopamine
- Dihydroergotamine intranasal + Dopamine Contraindicated
- Dihydroergotamine + Dopamine Contraindicated
- Dopamine + Promethazine Contraindicated
- Dopamine + Selegiline transdermal Contraindicated
- Amitriptyline + Dopamine Major
- Clomipramine + Dopamine Major
Other interactions of Epinephrine
- Epinephrine + Isocarboxazid Contraindicated
- Epinephrine + Phenelzine Contraindicated
- Epinephrine + Tranylcypromine Contraindicated
- Acebutolol + Epinephrine Major
- Amitriptyline + Epinephrine Major
- Amoxapine + Epinephrine Major
Frequently asked questions
Can I take Dopamine with Epinephrine?
MediHelp rates the interaction as moderate. Dopamine and Epinephrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents are sympathomimetics and their effects add together, causing greater increases in heart rate and blood pressure. Combined use raises the risk of tachyarrhythmias and myocardial ischemia, although it is sometimes done deliberately in shock.
How serious is the interaction between Dopamine and Epinephrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use continuous ECG and arterial blood pressure monitoring and titrate each infusion to the lowest effective dose.
What other medicines interact with Dopamine?
MediHelp also lists interactions of Dopamine with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Promethazine. The full list is on the Dopamine page.
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