Drug interactions
Dopamine + Ergoloid mesylates
Severity: Major
Dopamine and Ergoloid mesylates: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dopamine is a vasopressor that constricts peripheral vessels at higher doses, and ergoloid mesylates has some alpha-adrenergic and dopaminergic activity. The combination could produce excessive vasoconstriction and hypertension, although ergoloid has weaker vasoconstrictor effects than other ergot derivatives. The interaction is largely predicted rather than well documented.
What this interaction means in plain words
Dopamine and Ergoloid mesylates can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive pharmacodynamic vasoconstriction through adrenergic and ergot-related vascular effects.
What to do
Avoid the combination where possible; if dopamine is essential, monitor blood pressure continuously and check peripheral perfusion. Reduce or stop the infusion if hypertension or ischemic signs develop.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Dopamine
- Dihydroergotamine intranasal + Dopamine Contraindicated
- Dihydroergotamine + Dopamine Contraindicated
- Dopamine + Promethazine Contraindicated
- Dopamine + Selegiline transdermal Contraindicated
- Amitriptyline + Dopamine Major
- Clomipramine + Dopamine Major
Frequently asked questions
Can I take Dopamine with Ergoloid mesylates?
MediHelp rates the interaction as major. Dopamine and Ergoloid mesylates can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dopamine is a vasopressor that constricts peripheral vessels at higher doses, and ergoloid mesylates has some alpha-adrenergic and dopaminergic activity. The combination could produce excessive vasoconstriction and hypertension, although ergoloid has weaker vasoconstrictor effects than other ergot derivatives. The interaction is largely predicted rather than well documented.
How serious is the interaction between Dopamine and Ergoloid mesylates?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if dopamine is essential, monitor blood pressure continuously and check peripheral perfusion. Reduce or stop the infusion if hypertension or ischemic signs develop.
What other medicines interact with Dopamine?
MediHelp also lists interactions of Dopamine with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Promethazine. The full list is on the Dopamine page.
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