Drug interactions
Dopamine + Methylergonovine
Severity: Major
Dopamine and Methylergonovine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs constrict blood vessels, and together they can cause severe vasospasm with marked hypertension. Peripheral ischemia and cerebrovascular events are possible. Reports with vasopressors and ergot alkaloids support the risk.
What this interaction means in plain words
Dopamine and Methylergonovine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive vasoconstriction through adrenergic effects of dopamine and serotonergic and alpha-adrenergic vascular effects of the ergot.
What to do
Avoid concurrent use where possible. If both are needed, monitor blood pressure continuously and watch for limb or cerebral ischemia, lowering the dopamine dose if hypertension occurs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Dopamine
- Dihydroergotamine intranasal + Dopamine Contraindicated
- Dihydroergotamine + Dopamine Contraindicated
- Dopamine + Promethazine Contraindicated
- Dopamine + Selegiline transdermal Contraindicated
- Amitriptyline + Dopamine Major
- Clomipramine + Dopamine Major
Frequently asked questions
Can I take Dopamine with Methylergonovine?
MediHelp rates the interaction as major. Dopamine and Methylergonovine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs constrict blood vessels, and together they can cause severe vasospasm with marked hypertension. Peripheral ischemia and cerebrovascular events are possible. Reports with vasopressors and ergot alkaloids support the risk.
How serious is the interaction between Dopamine and Methylergonovine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible. If both are needed, monitor blood pressure continuously and watch for limb or cerebral ischemia, lowering the dopamine dose if hypertension occurs.
What other medicines interact with Dopamine?
MediHelp also lists interactions of Dopamine with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Promethazine. The full list is on the Dopamine page.
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