Drug interactions
Dopamine + Yohimbine
Severity: Moderate
Dopamine and Yohimbine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Yohimbine blocks alpha-2 receptors and increases noradrenergic outflow, which can raise blood pressure and heart rate. Combined with dopamine, pressor and chronotropic effects may be additive and unpredictable.
What this interaction means in plain words
Dopamine and Yohimbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Alpha-2 antagonism by yohimbine increases norepinephrine release, adding to dopamine's adrenergic stimulation.
What to do
Monitor blood pressure and heart rate closely during dopamine infusion and avoid yohimbine in patients receiving vasopressors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dopamine
- Dihydroergotamine intranasal + Dopamine Contraindicated
- Dihydroergotamine + Dopamine Contraindicated
- Dopamine + Promethazine Contraindicated
- Dopamine + Selegiline transdermal Contraindicated
- Amitriptyline + Dopamine Major
- Clomipramine + Dopamine Major
Frequently asked questions
Can I take Dopamine with Yohimbine?
MediHelp rates the interaction as moderate. Dopamine and Yohimbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Yohimbine blocks alpha-2 receptors and increases noradrenergic outflow, which can raise blood pressure and heart rate. Combined with dopamine, pressor and chronotropic effects may be additive and unpredictable.
How serious is the interaction between Dopamine and Yohimbine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate closely during dopamine infusion and avoid yohimbine in patients receiving vasopressors.
What other medicines interact with Dopamine?
MediHelp also lists interactions of Dopamine with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Promethazine. The full list is on the Dopamine page.
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