Drug interactions
Dopexamine + Sotalol
Severity: Moderate
Dopexamine and Sotalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotalol blocks beta-2 receptors and opposes the hemodynamic effects of dopexamine, an agonist of beta-2 and dopamine receptors. Dopexamine can also lower potassium, adding proarrhythmic risk with sotalol.
What this interaction means in plain words
Dopexamine and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism at beta-adrenoceptors plus agonist-induced intracellular potassium shift.
What to do
Monitor hemodynamics and serum potassium, and expect a reduced dopexamine response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Frequently asked questions
Can I take Dopexamine with Sotalol?
MediHelp rates the interaction as moderate. Dopexamine and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sotalol blocks beta-2 receptors and opposes the hemodynamic effects of dopexamine, an agonist of beta-2 and dopamine receptors. Dopexamine can also lower potassium, adding proarrhythmic risk with sotalol.
How serious is the interaction between Dopexamine and Sotalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor hemodynamics and serum potassium, and expect a reduced dopexamine response.
What other medicines interact with Sotalol?
MediHelp also lists interactions of Sotalol with, for example, Arsenic trioxide, Artemether / lumefantrine, Disopyramide. The full list is on the Sotalol page.
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