Drug interactions
Dopexamine + Trazodone
Severity: Moderate
Dopexamine and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dopexamine is a catecholamine-like agent with beta-2 and dopaminergic effects, and trazodone's alpha-blocking properties may change the hemodynamic response. Blood pressure and heart rate may be less predictable, and hypotension is possible.
What this interaction means in plain words
Dopexamine and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic interaction between adrenergic stimulation and trazodone's alpha-adrenergic blockade; not well characterized.
What to do
Monitor blood pressure and heart rate continuously during dopexamine infusion in patients taking trazodone. Titrate the infusion to hemodynamic response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Dopexamine with Trazodone?
MediHelp rates the interaction as moderate. Dopexamine and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dopexamine is a catecholamine-like agent with beta-2 and dopaminergic effects, and trazodone's alpha-blocking properties may change the hemodynamic response. Blood pressure and heart rate may be less predictable, and hypotension is possible.
How serious is the interaction between Dopexamine and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate continuously during dopexamine infusion in patients taking trazodone. Titrate the infusion to hemodynamic response.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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