Drug interactions
Dosulepin + Hydroxyzine
Severity: Moderate
Dosulepin and Hydroxyzine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dosulepin is a sedating tricyclic antidepressant and hydroxyzine is a sedating antihistamine, so combined use increases drowsiness and anticholinergic effects. Both may also contribute to QT prolongation and arrhythmia risk in susceptible patients, and dosulepin is dangerous in overdose.
What this interaction means in plain words
Dosulepin and Hydroxyzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dosulepin belongs to Central Nervous System; Hydroxyzine belongs to Respiratory.
Why it happens
Additive CNS depression, antimuscarinic effects and QT prolongation.
What to do
Use the lowest effective doses and monitor sedation and anticholinergic symptoms. Consider an ECG in patients with cardiac risk factors or other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Other interactions of Dosulepin
- Dosulepin + Isocarboxazid Contraindicated
- Dosulepin + Phenelzine Contraindicated
- Dosulepin + Thioridazine Contraindicated
- Dosulepin + Tranylcypromine Contraindicated
- Amitriptyline + Dosulepin Major
- Buprenorphine + Dosulepin Major
Frequently asked questions
Can I take Dosulepin with Hydroxyzine?
MediHelp rates the interaction as moderate. Dosulepin and Hydroxyzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dosulepin is a sedating tricyclic antidepressant and hydroxyzine is a sedating antihistamine, so combined use increases drowsiness and anticholinergic effects. Both may also contribute to QT prolongation and arrhythmia risk in susceptible patients, and dosulepin is dangerous in overdose.
How serious is the interaction between Dosulepin and Hydroxyzine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor sedation and anticholinergic symptoms. Consider an ECG in patients with cardiac risk factors or other QT-prolonging drugs.
What other medicines interact with Hydroxyzine?
MediHelp also lists interactions of Hydroxyzine with, for example, Droperidol, Pimozide, Thioridazine. The full list is on the Hydroxyzine page.
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