Drug interactions
Dosulepin + Indacaterol-glycopyrronium
Severity: Moderate
Dosulepin and Indacaterol-glycopyrronium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dosulepin is a tricyclic antidepressant with significant anticholinergic properties. With glycopyrronium, anticholinergic effects such as dry mouth, constipation, urinary retention and blurred vision may be additive. Tricyclics may also potentiate the cardiovascular effects of beta2-agonists such as indacaterol and prolong QT.
What this interaction means in plain words
Dosulepin and Indacaterol-glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dosulepin belongs to Central Nervous System; Indacaterol-glycopyrronium belongs to Respiratory.
Why it happens
Additive antimuscarinic effects; tricyclic antidepressants can also increase the cardiovascular effects of beta2-agonists and prolong QT.
What to do
Monitor for anticholinergic effects and palpitations, and consider an ECG in patients with cardiac risk factors. Avoid use in patients with narrow-angle glaucoma or urinary retention.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol-glycopyrronium
Other interactions of Dosulepin
- Dosulepin + Isocarboxazid Contraindicated
- Dosulepin + Phenelzine Contraindicated
- Dosulepin + Thioridazine Contraindicated
- Dosulepin + Tranylcypromine Contraindicated
- Amitriptyline + Dosulepin Major
- Buprenorphine + Dosulepin Major
Frequently asked questions
Can I take Dosulepin with Indacaterol-glycopyrronium?
MediHelp rates the interaction as moderate. Dosulepin and Indacaterol-glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dosulepin is a tricyclic antidepressant with significant anticholinergic properties. With glycopyrronium, anticholinergic effects such as dry mouth, constipation, urinary retention and blurred vision may be additive. Tricyclics may also potentiate the cardiovascular effects of beta2-agonists such as indacaterol and prolong QT.
How serious is the interaction between Dosulepin and Indacaterol-glycopyrronium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects and palpitations, and consider an ECG in patients with cardiac risk factors. Avoid use in patients with narrow-angle glaucoma or urinary retention.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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