Drug interactions
Dosulepin + Midazolam
Severity: Moderate
Dosulepin and Midazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dosulepin is a sedating tricyclic antidepressant, and with midazolam it increases drowsiness and impaired psychomotor performance. Respiratory depression is possible at higher doses or in vulnerable patients.
What this interaction means in plain words
Dosulepin and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dosulepin belongs to Central Nervous System; Midazolam belongs to Central Nervous System.
Why it happens
Additive CNS depression via GABA-A potentiation and antihistaminic/anticholinergic effects of the tricyclic.
What to do
Use a lower initial midazolam dose and titrate cautiously. Monitor sedation and respiration, and warn outpatients about driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Other interactions of Dosulepin
- Dosulepin + Isocarboxazid Contraindicated
- Dosulepin + Phenelzine Contraindicated
- Dosulepin + Thioridazine Contraindicated
- Dosulepin + Tranylcypromine Contraindicated
- Amitriptyline + Dosulepin Major
- Buprenorphine + Dosulepin Major
Frequently asked questions
Can I take Dosulepin with Midazolam?
MediHelp rates the interaction as moderate. Dosulepin and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dosulepin is a sedating tricyclic antidepressant, and with midazolam it increases drowsiness and impaired psychomotor performance. Respiratory depression is possible at higher doses or in vulnerable patients.
How serious is the interaction between Dosulepin and Midazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a lower initial midazolam dose and titrate cautiously. Monitor sedation and respiration, and warn outpatients about driving.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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