Drug interactions
Dosulepin + Solifenacin
Severity: Moderate
Dosulepin and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dosulepin is a tricyclic antidepressant with notable anticholinergic activity. Together with solifenacin it can cause additive dry mouth, constipation, urinary retention, blurred vision and cognitive impairment.
What this interaction means in plain words
Dosulepin and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dosulepin belongs to Central Nervous System; Solifenacin belongs to Genitourinary.
Why it happens
Additive muscarinic receptor antagonism.
What to do
Monitor for anticholinergic burden, especially in older adults, and reduce doses or switch to a less anticholinergic antidepressant if effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Other interactions of Dosulepin
- Dosulepin + Isocarboxazid Contraindicated
- Dosulepin + Phenelzine Contraindicated
- Dosulepin + Thioridazine Contraindicated
- Dosulepin + Tranylcypromine Contraindicated
- Amitriptyline + Dosulepin Major
- Buprenorphine + Dosulepin Major
Frequently asked questions
Can I take Dosulepin with Solifenacin?
MediHelp rates the interaction as moderate. Dosulepin and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dosulepin is a tricyclic antidepressant with notable anticholinergic activity. Together with solifenacin it can cause additive dry mouth, constipation, urinary retention, blurred vision and cognitive impairment.
How serious is the interaction between Dosulepin and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic burden, especially in older adults, and reduce doses or switch to a less anticholinergic antidepressant if effects emerge.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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