Drug interactions
Doxazosin + Sotalol
Severity: Moderate
Doxazosin and Sotalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The blood pressure lowering effects add together, and first-dose hypotension from doxazosin may be more severe or prolonged. Sotalol also slows heart rate, which may limit compensatory responses.
What this interaction means in plain words
Doxazosin and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxazosin belongs to Genitourinary; Sotalol belongs to Cardiovascular.
Why it happens
Additive hypotension from alpha-1 adrenergic blockade and beta blockade.
What to do
Initiate doxazosin at a low dose and titrate slowly while monitoring blood pressure and heart rate. Counsel the patient about orthostatic symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxazosin
- Alfuzosin + Doxazosin Major
- Amifostine + Doxazosin Major
- Avanafil + Doxazosin Major
- Doxazosin + Dutasteride-tamsulosin Major
- Doxazosin + Phentolamine Major
- Doxazosin + Prazosin Major
Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Frequently asked questions
Can I take Doxazosin with Sotalol?
MediHelp rates the interaction as moderate. Doxazosin and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The blood pressure lowering effects add together, and first-dose hypotension from doxazosin may be more severe or prolonged. Sotalol also slows heart rate, which may limit compensatory responses.
How serious is the interaction between Doxazosin and Sotalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Initiate doxazosin at a low dose and titrate slowly while monitoring blood pressure and heart rate. Counsel the patient about orthostatic symptoms.
What other medicines interact with Doxazosin?
MediHelp also lists interactions of Doxazosin with, for example, Alfuzosin, Amifostine, Avanafil. The full list is on the Doxazosin page.
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