Drug interactions
Doxepin + Glimepiride
Severity: Minor
Doxepin and Glimepiride: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants such as doxepin have been associated with altered glucose regulation, and may enhance hypoglycemia with sulfonylureas in some patients. They can also mask adrenergic warning symptoms of low blood sugar.
What this interaction means in plain words
Doxepin and Glimepiride have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Doxepin belongs to Dermatology; Glimepiride belongs to Endocrine.
Why it happens
Proposed effects on insulin secretion and glucose metabolism add to the sulfonylurea effect; the mechanism is not well defined.
What to do
Monitor blood glucose when doxepin is started or the dose is changed. Educate the patient about hypoglycemia symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Doxepin and Glimepiride, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Glimepiride
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Doxepin with Glimepiride?
MediHelp rates the interaction as minor. Doxepin and Glimepiride have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tricyclic antidepressants such as doxepin have been associated with altered glucose regulation, and may enhance hypoglycemia with sulfonylureas in some patients. They can also mask adrenergic warning symptoms of low blood sugar.
How serious is the interaction between Doxepin and Glimepiride?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when doxepin is started or the dose is changed. Educate the patient about hypoglycemia symptoms.
What other medicines interact with Glimepiride?
MediHelp also lists interactions of Glimepiride with, for example, Fluconazole, Insulin degludec-liraglutide, Insulin glargine-lixisenatide. The full list is on the Glimepiride page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
