Drug interactions
Doxepin + Glycopyrronium
Severity: Moderate
Doxepin and Glycopyrronium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxepin is a tricyclic with strong anticholinergic activity, so combining it with glycopyrronium adds to dry mouth, constipation, urinary retention, blurred vision and confusion. Older patients are at particular risk.
What this interaction means in plain words
Doxepin and Glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxepin belongs to Dermatology; Glycopyrronium belongs to Respiratory.
Why it happens
Additive antimuscarinic effects at peripheral and central receptors.
What to do
Monitor for urinary retention, constipation, tachycardia and confusion. Reduce doses or choose a less anticholinergic antidepressant if effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glycopyrronium
- Clozapine + Glycopyrronium Major
- Glycopyrronium + Potassium chloride Major
- Abobotulinumtoxina + Glycopyrronium Moderate
- Aclidinium + Glycopyrronium Moderate
- Amantadine + Glycopyrronium Moderate
- Amitriptyline + Glycopyrronium Moderate
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Doxepin with Glycopyrronium?
MediHelp rates the interaction as moderate. Doxepin and Glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Doxepin is a tricyclic with strong anticholinergic activity, so combining it with glycopyrronium adds to dry mouth, constipation, urinary retention, blurred vision and confusion. Older patients are at particular risk.
How serious is the interaction between Doxepin and Glycopyrronium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for urinary retention, constipation, tachycardia and confusion. Reduce doses or choose a less anticholinergic antidepressant if effects emerge.
What other medicines interact with Glycopyrronium?
MediHelp also lists interactions of Glycopyrronium with, for example, Clozapine, Potassium chloride, Abobotulinumtoxina. The full list is on the Glycopyrronium page.
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