Drug interactions
Doxepin + Imatinib
Severity: Moderate
Doxepin and Imatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxepin is metabolised by CYP2D6, CYP2C19 and CYP3A4, and imatinib inhibits CYP2D6 and CYP3A4. Higher doxepin levels may cause more sedation, anticholinergic effects and QT or cardiac conduction effects.
What this interaction means in plain words
Doxepin and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxepin belongs to Dermatology; Imatinib belongs to Oncology.
Why it happens
Imatinib inhibits CYP2D6 and CYP3A4, reducing doxepin clearance.
What to do
Monitor for sedation, anticholinergic effects and arrhythmia, and consider lowering the doxepin dose. Check ECG if there are other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Doxepin with Imatinib?
MediHelp rates the interaction as moderate. Doxepin and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Doxepin is metabolised by CYP2D6, CYP2C19 and CYP3A4, and imatinib inhibits CYP2D6 and CYP3A4. Higher doxepin levels may cause more sedation, anticholinergic effects and QT or cardiac conduction effects.
How serious is the interaction between Doxepin and Imatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, anticholinergic effects and arrhythmia, and consider lowering the doxepin dose. Check ECG if there are other QT risk factors.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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