Drug interactions
Doxepin + Ipratropium-salbutamol
Severity: Moderate
Doxepin and Ipratropium-salbutamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxepin may enhance the cardiovascular effects of salbutamol, including tachycardia and arrhythmia. Its anticholinergic effects may also add to those of ipratropium.
What this interaction means in plain words
Doxepin and Ipratropium-salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxepin belongs to Dermatology; Ipratropium-salbutamol belongs to Respiratory.
Why it happens
Tricyclic inhibition of norepinephrine reuptake and additive adrenergic and anticholinergic effects.
What to do
Monitor heart rate, rhythm and blood pressure; reduce the beta-agonist dose if cardiovascular effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ipratropium-salbutamol
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Doxepin with Ipratropium-salbutamol?
MediHelp rates the interaction as moderate. Doxepin and Ipratropium-salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Doxepin may enhance the cardiovascular effects of salbutamol, including tachycardia and arrhythmia. Its anticholinergic effects may also add to those of ipratropium.
How serious is the interaction between Doxepin and Ipratropium-salbutamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, rhythm and blood pressure; reduce the beta-agonist dose if cardiovascular effects occur.
What other medicines interact with Ipratropium-salbutamol?
MediHelp also lists interactions of Ipratropium-salbutamol with, for example, Amisulpride, Arsenic trioxide, Carvedilol. The full list is on the Ipratropium-salbutamol page.
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