Drug interactions
Doxepin + Linagliptin-metformin
Severity: Minor
Doxepin and Linagliptin-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants like doxepin can alter glucose regulation and may mask adrenergic symptoms of hypoglycemia. Significant effects with metformin and linagliptin are uncommon.
What this interaction means in plain words
Doxepin and Linagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Doxepin belongs to Dermatology; Linagliptin-metformin belongs to Endocrine.
Why it happens
Possible pharmacodynamic effects on glucose regulation; the mechanism is not well established.
What to do
Monitor blood glucose when doxepin is started or adjusted. No routine dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Linagliptin-metformin
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Doxepin with Linagliptin-metformin?
MediHelp rates the interaction as minor. Doxepin and Linagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tricyclic antidepressants like doxepin can alter glucose regulation and may mask adrenergic symptoms of hypoglycemia. Significant effects with metformin and linagliptin are uncommon.
How serious is the interaction between Doxepin and Linagliptin-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when doxepin is started or adjusted. No routine dose change is needed.
What other medicines interact with Linagliptin-metformin?
MediHelp also lists interactions of Linagliptin-metformin with, for example, Apalutamide, Carbamazepine, Contrast media. The full list is on the Linagliptin-metformin page.
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