Drug interactions
Doxepin + Loxapine
Severity: Moderate
Doxepin and Loxapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation and anticholinergic effects, and both can prolong the QT interval and lower the seizure threshold. The combination may cause marked drowsiness, hypotension, and anticholinergic toxicity.
What this interaction means in plain words
Doxepin and Loxapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxepin belongs to Dermatology; Loxapine belongs to Central Nervous System.
Why it happens
Additive CNS depression, anticholinergic effects, and possible QT prolongation; doxepin may also modestly inhibit CYP2D6.
What to do
Use the lowest effective doses and monitor sedation, anticholinergic symptoms, blood pressure, and ECG if risk factors for QT prolongation exist. Take extra care in elderly patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Loxapine
- Alfentanil + Loxapine Major
- Alprazolam + Loxapine Major
- Amisulpride + Loxapine Major
- Amoxapine + Loxapine Major
- Apomorphine + Loxapine Major
- Belladonna and opium + Loxapine Major
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Doxepin with Loxapine?
MediHelp rates the interaction as moderate. Doxepin and Loxapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation and anticholinergic effects, and both can prolong the QT interval and lower the seizure threshold. The combination may cause marked drowsiness, hypotension, and anticholinergic toxicity.
How serious is the interaction between Doxepin and Loxapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor sedation, anticholinergic symptoms, blood pressure, and ECG if risk factors for QT prolongation exist. Take extra care in elderly patients.
What other medicines interact with Loxapine?
MediHelp also lists interactions of Loxapine with, for example, Alfentanil, Alprazolam, Amisulpride. The full list is on the Loxapine page.
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