Drug interactions
Doxepin + Methocarbamol
Severity: Moderate
Doxepin and Methocarbamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxepin is a sedating tricyclic antidepressant with strong antihistamine activity. With methocarbamol, drowsiness, dizziness and psychomotor impairment can be additive, and anticholinergic effects may add to the burden in older patients.
What this interaction means in plain words
Doxepin and Methocarbamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxepin belongs to Dermatology; Methocarbamol belongs to Musculoskeletal.
Why it happens
Additive CNS depression from H1-antihistaminic sedation of doxepin and the central action of methocarbamol.
What to do
Monitor for oversedation and falls, particularly in the elderly, and consider lower doses of either drug. Counsel against driving until tolerance is established.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methocarbamol
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Doxepin with Methocarbamol?
MediHelp rates the interaction as moderate. Doxepin and Methocarbamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Doxepin is a sedating tricyclic antidepressant with strong antihistamine activity. With methocarbamol, drowsiness, dizziness and psychomotor impairment can be additive, and anticholinergic effects may add to the burden in older patients.
How serious is the interaction between Doxepin and Methocarbamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and falls, particularly in the elderly, and consider lower doses of either drug. Counsel against driving until tolerance is established.
What other medicines interact with Methocarbamol?
MediHelp also lists interactions of Methocarbamol with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Methocarbamol page.
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