Drug interactions
Doxepin + Naratriptan
Severity: Moderate
Doxepin and Naratriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs increase serotonergic activity, so serotonin syndrome is a rare possibility with combined use. Clinical evidence is limited and the risk appears low.
What this interaction means in plain words
Doxepin and Naratriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxepin belongs to Dermatology; Naratriptan belongs to Central Nervous System.
Why it happens
Additive serotonergic effects from triptan receptor agonism and doxepin inhibition of serotonin reuptake.
What to do
Monitor for tremor, agitation, sweating, hyperthermia and clonus after starting or changing doses. Discontinue serotonergic agents if serotonin syndrome is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Naratriptan
- Almotriptan + Naratriptan Contraindicated
- Dihydroergotamine intranasal + Naratriptan Contraindicated
- Dihydroergotamine + Naratriptan Contraindicated
- Eletriptan + Naratriptan Contraindicated
- Ergoloid mesylates + Naratriptan Contraindicated
- Ergotamine + Naratriptan Contraindicated
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Doxepin with Naratriptan?
MediHelp rates the interaction as moderate. Doxepin and Naratriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs increase serotonergic activity, so serotonin syndrome is a rare possibility with combined use. Clinical evidence is limited and the risk appears low.
How serious is the interaction between Doxepin and Naratriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tremor, agitation, sweating, hyperthermia and clonus after starting or changing doses. Discontinue serotonergic agents if serotonin syndrome is suspected.
What other medicines interact with Naratriptan?
MediHelp also lists interactions of Naratriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Naratriptan page.
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