Drug interactions
Doxepin + Orphenadrin
Severity: Moderate
Doxepin and Orphenadrin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxepin is a sedating tricyclic antidepressant with strong anticholinergic and antihistaminic effects, and orphenadrine adds to both. The combination can cause marked drowsiness, confusion, dry mouth, constipation, urinary retention and tachycardia.
What this interaction means in plain words
Doxepin and Orphenadrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxepin belongs to Dermatology; Orphenadrin belongs to Musculoskeletal.
Why it happens
Additive antimuscarinic and CNS depressant effects.
What to do
Monitor for anticholinergic toxicity and sedation, especially in older adults. Reduce doses or choose alternatives if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Orphenadrin
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Doxepin with Orphenadrin?
MediHelp rates the interaction as moderate. Doxepin and Orphenadrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Doxepin is a sedating tricyclic antidepressant with strong anticholinergic and antihistaminic effects, and orphenadrine adds to both. The combination can cause marked drowsiness, confusion, dry mouth, constipation, urinary retention and tachycardia.
How serious is the interaction between Doxepin and Orphenadrin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity and sedation, especially in older adults. Reduce doses or choose alternatives if symptoms develop.
What other medicines interact with Orphenadrin?
MediHelp also lists interactions of Orphenadrin with, for example, Alfentanil, Amobarbital, Benzhydrocodone / acetaminophen. The full list is on the Orphenadrin page.
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