Drug interactions
Doxepin + Pancuronium
Severity: Moderate
Doxepin and Pancuronium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxepin has anticholinergic properties, and pancuronium has mild vagolytic effects, so heart rate may increase further. Tachycardia and arrhythmia are the main concern in susceptible patients during anesthesia.
What this interaction means in plain words
Doxepin and Pancuronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxepin belongs to Dermatology; Pancuronium belongs to Musculoskeletal.
Why it happens
Additive antimuscarinic effects of doxepin and pancuronium's vagolytic action, with tricyclic-related arrhythmia propensity.
What to do
Monitor ECG and heart rate during anesthesia in patients taking doxepin and treat significant tachyarrhythmia promptly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pancuronium
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Doxepin with Pancuronium?
MediHelp rates the interaction as moderate. Doxepin and Pancuronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Doxepin has anticholinergic properties, and pancuronium has mild vagolytic effects, so heart rate may increase further. Tachycardia and arrhythmia are the main concern in susceptible patients during anesthesia.
How serious is the interaction between Doxepin and Pancuronium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and heart rate during anesthesia in patients taking doxepin and treat significant tachyarrhythmia promptly.
What other medicines interact with Pancuronium?
MediHelp also lists interactions of Pancuronium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Capreomycin. The full list is on the Pancuronium page.
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