Drug interactions
Amisulpride + Doxepin
Severity: Major
Amisulpride and Doxepin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can prolong the QT interval, so combined use raises the risk of torsades de pointes, especially with doxepin at antidepressant doses. Additive sedation and anticholinergic effects may also occur.
What this interaction means in plain words
Amisulpride and Doxepin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amisulpride belongs to Central Nervous System; Doxepin belongs to Dermatology.
Why it happens
Additive QT prolongation through cardiac potassium channel blockade, plus additive CNS depression.
What to do
Obtain a baseline ECG and monitor it after starting or changing doses, and correct potassium and magnesium. Avoid the combination in patients with long QT, bradycardia or other QT-prolonging drugs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amisulpride
- Amiodarone + Amisulpride Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Amisulpride + Disopyramide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amisulpride + Droperidol Contraindicated
- Amisulpride + Ibutilide Contraindicated
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Amisulpride with Doxepin?
MediHelp rates the interaction as major. Amisulpride and Doxepin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents can prolong the QT interval, so combined use raises the risk of torsades de pointes, especially with doxepin at antidepressant doses. Additive sedation and anticholinergic effects may also occur.
How serious is the interaction between Amisulpride and Doxepin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor it after starting or changing doses, and correct potassium and magnesium. Avoid the combination in patients with long QT, bradycardia or other QT-prolonging drugs.
What other medicines interact with Amisulpride?
MediHelp also lists interactions of Amisulpride with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Amisulpride page.
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