Drug interactions
Doxepin + Sitagliptin
Severity: Minor
Doxepin and Sitagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants like doxepin can alter glucose regulation, causing either hypoglycemia or hyperglycemia, and may increase appetite and weight. Sitagliptin alone has a low hypoglycemia risk, so the clinical significance is small.
What this interaction means in plain words
Doxepin and Sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Doxepin belongs to Dermatology; Sitagliptin belongs to Endocrine.
Why it happens
Pharmacodynamic: tricyclic effects on insulin sensitivity, appetite and glucose handling; the mechanism is not well established.
What to do
Monitor blood glucose when doxepin is started or changed in a patient with diabetes, and adjust therapy if control shifts.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sitagliptin
- Albiglutide + Sitagliptin Moderate
- Amlodipine-benazepril + Sitagliptin Moderate
- Aripiprazole + Sitagliptin Moderate
- Asenapine + Sitagliptin Moderate
- Benazepril + Sitagliptin Moderate
- Captopril-hydrochlorothiazide + Sitagliptin Moderate
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Doxepin with Sitagliptin?
MediHelp rates the interaction as minor. Doxepin and Sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tricyclic antidepressants like doxepin can alter glucose regulation, causing either hypoglycemia or hyperglycemia, and may increase appetite and weight. Sitagliptin alone has a low hypoglycemia risk, so the clinical significance is small.
How serious is the interaction between Doxepin and Sitagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when doxepin is started or changed in a patient with diabetes, and adjust therapy if control shifts.
What other medicines interact with Sitagliptin?
MediHelp also lists interactions of Sitagliptin with, for example, Albiglutide, Amlodipine-benazepril, Aripiprazole. The full list is on the Sitagliptin page.
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