Drug interactions
Doxepin + Tiotropium
Severity: Minor
Doxepin and Tiotropium: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxepin is a tricyclic antidepressant with notable anticholinergic activity that can add to tiotropium's effects. This may increase dry mouth, constipation, urinary retention and blurred vision.
What this interaction means in plain words
Doxepin and Tiotropium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Doxepin belongs to Dermatology; Tiotropium belongs to Respiratory.
Why it happens
Additive antimuscarinic effects.
What to do
Monitor for anticholinergic symptoms, especially in the elderly or those with glaucoma or prostatic hypertrophy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tiotropium
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Doxepin with Tiotropium?
MediHelp rates the interaction as minor. Doxepin and Tiotropium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Doxepin is a tricyclic antidepressant with notable anticholinergic activity that can add to tiotropium's effects. This may increase dry mouth, constipation, urinary retention and blurred vision.
How serious is the interaction between Doxepin and Tiotropium?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic symptoms, especially in the elderly or those with glaucoma or prostatic hypertrophy.
What other medicines interact with Tiotropium?
MediHelp also lists interactions of Tiotropium with, for example, Glycopyrrolate inhaled, Indacaterol-glycopyrronium, Revefenacin. The full list is on the Tiotropium page.
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