Drug interactions
Doxepin + Tolbutamide
Severity: Minor
Doxepin and Tolbutamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants such as doxepin have been associated with altered glycemic control and may enhance hypoglycemia in patients on sulfonylureas. They can also blunt or mask some adrenergic warning symptoms. The effect is variable and generally modest.
What this interaction means in plain words
Doxepin and Tolbutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Doxepin belongs to Dermatology; Tolbutamide belongs to Endocrine.
Why it happens
Possible additive effect on glucose lowering through altered insulin sensitivity or secretion; mechanism is not well established.
What to do
Monitor blood glucose when doxepin is started, changed or stopped and adjust the tolbutamide dose as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolbutamide
- Glyburide-metformin + Tolbutamide Major
- Insulin degludec-liraglutide + Tolbutamide Major
- Aceclofenac + Tolbutamide Moderate
- Acemetacin + Tolbutamide Moderate
- Acetylsalicylic acid + Tolbutamide Moderate
- Albiglutide + Tolbutamide Moderate
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Doxepin with Tolbutamide?
MediHelp rates the interaction as minor. Doxepin and Tolbutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tricyclic antidepressants such as doxepin have been associated with altered glycemic control and may enhance hypoglycemia in patients on sulfonylureas. They can also blunt or mask some adrenergic warning symptoms. The effect is variable and generally modest.
How serious is the interaction between Doxepin and Tolbutamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when doxepin is started, changed or stopped and adjust the tolbutamide dose as needed.
What other medicines interact with Tolbutamide?
MediHelp also lists interactions of Tolbutamide with, for example, Glyburide-metformin, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolbutamide page.
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