Drug interactions
Doxepin + Vardenafil
Severity: Moderate
Doxepin and Vardenafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxepin, a tricyclic antidepressant, can prolong QT at higher doses, and vardenafil adds a modest QT effect. Risk is greater with high doses or other risk factors.
What this interaction means in plain words
Doxepin and Vardenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxepin belongs to Dermatology; Vardenafil belongs to Genitourinary.
Why it happens
Additive QT interval prolongation.
What to do
Monitor ECG in patients with cardiac disease or electrolyte disturbances, and use the lowest effective doxepin dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vardenafil
- Amyl nitrite + Vardenafil Contraindicated
- Glyceryl trinitrate pr + Vardenafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Isosorbide mononitrate + Vardenafil Contraindicated
- Nicorandil + Vardenafil Contraindicated
- Nitroglycerin po + Vardenafil Contraindicated
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Doxepin with Vardenafil?
MediHelp rates the interaction as moderate. Doxepin and Vardenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Doxepin, a tricyclic antidepressant, can prolong QT at higher doses, and vardenafil adds a modest QT effect. Risk is greater with high doses or other risk factors.
How serious is the interaction between Doxepin and Vardenafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG in patients with cardiac disease or electrolyte disturbances, and use the lowest effective doxepin dose.
What other medicines interact with Vardenafil?
MediHelp also lists interactions of Vardenafil with, for example, Amyl nitrite, Glyceryl trinitrate pr, Isosorbide dinitrate. The full list is on the Vardenafil page.
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